S100A8 / S100A9(MRP(8/14)是一種鈣結合蛋白,由中性粒細胞和單核細胞分泌而成,糞便中S100A8 / S100A9是贅生性和炎癥性胃腸疾病的標志物,一般情況下很難區(qū)分腸易激綜合癥和慢性炎癥性腸病,所以很多時候會導致廣泛和不必要結腸鏡檢查,而S100A8 / S100A9檢測可以使兩組患者明確區(qū)分。將該標記物與結腸直腸癌的標準糞便潛血篩查進行比較,能夠清楚地證明了糞便S100A8 / S100A9測試的診斷優(yōu)勢,該參數(shù)具有較高的診斷價值:如果糞便中的S100A8 / S100A9水平較低,則很可能不存在器質性疾病。
Immundiagnostik(IDK)公司能提供大/小鼠鈣結合蛋白S100A8/S100A9檢測試劑盒(酶聯(lián)免疫法) ,用于定量大/小鼠糞便、血清、尿液、組織提取液及細胞培養(yǎng)上清液中的S100A8/S100A9(鈣衛(wèi)蛋白MRP8/14 )。
貨號
KR
6936
品名
S100A8/A9
(MRP8/14, Calprotectin, Mouse/Rat) ELISA
規(guī)格
96tests
孵育時間
1h/1h/1h/5-15min
樣本類型
大/小鼠糞便,血清,尿液,組織提取液
樣本量
100μl/100mg
校準品
0.25-15.6ng/ml
方法
酶聯(lián)免疫法
品牌
IMMUNDIAGNOSTIK
儲存條件
2-8℃
產(chǎn)品說明
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- Nelson, D. a et al., 2012. An expanded myeloid derived suppressor cell population does not play a role in gammaherpesvirus-exacerbated breast cancer metastases. Infectious agents and cancer, 7(1), p.22. Manual S100A8/S100A9 (MRP8/14) 24
- Prinzen, C. et al., 2009. Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice. BMC genomics, 10, p.66.
- Soro-Paavonen, A. et al., 2008. Receptor for advanced glycation end products (RAGE) deficiency attenuates the development of atherosclerosis in diabetes. Diabetes, 57(9), pp.2461–2469.
- Volz, H.C. et al., 2012. S100A8/A9 aggravates post-ischemic heart failure through activation of RAGE-dependent NF-κB signaling. Basic research in cardiology, 107(2), p.250.
- Wiechert, L. et al., 2012. Hepatocyte-specific S100a8 and S100a9 transgene expression in mice causes Cxcl1 induction and systemic neutrophil enrichment. Cell communication and signaling : CCS, 10(1), p.40.
- Yamamoto, Y. et al., 2011. Septic shock is associated with receptor for advanced glycation end products ligation of LPS. Journal of immunology (Baltimore, Md. : 1950), 186(5), pp.3248–57.
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